Yersinia pestis CO92Δ yopH Is a Potent Live, Attenuated Plague Vaccine
نویسندگان
چکیده
منابع مشابه
The smpB-ssrA mutant of Yersinia pestis functions as a live attenuated vaccine to protect mice against pulmonary plague infection.
The bacterial SmpB-SsrA system is a highly conserved translational quality control mechanism that helps maintain the translational machinery at full capacity. Here we present evidence to demonstrate that the smpB-ssrA genes are required for pathogenesis of Yersinia pestis, the causative agent of plague. We found that disruption of the smpB-ssrA genes leads to reduction in secretion of the type ...
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ژورنال
عنوان ژورنال: Clinical and Vaccine Immunology
سال: 2007
ISSN: 1556-6811,1556-679X
DOI: 10.1128/cvi.00137-07